IgG isotype and isotype specificity of murine monoclonal IgG rheumatoid factors
نویسندگان
چکیده
منابع مشابه
[Immunoglobulin isotype and IgG subclass profiles in American tegumentary leishmaniasis].
The present work investigated the serum antibody profiles in 37 patients with American tegumentary leishmaniasis, who were attended at Hospital de Clinicas - Universidade Federal de Uberlandia, MG, Brazil. The immunoglobulin class and IgG subclass profiles were analyzed by indirect ELISA using Leishmania (Leishmania) amazonensis soluble antigen. The antibody avidity was determined by 6 M urea t...
متن کاملThe isotype and IgG subclass distribution of anti-carbamylated protein antibodies in rheumatoid arthritis patients
BACKGROUND Anti-carbamylated protein (anti-CarP) antibodies have recently been reported to occur in around 45% of rheumatoid arthritis (RA) patients and to have prognostic and diagnostic properties. At present, the breadth and molecular make-up of the anti-CarP antibody response is ill defined. To understand the anti-CarP antibody immune response and potential immune effector mechanisms it can ...
متن کاملLevels of immunoglobulins of isotype IgG and IgG2 in subjects lacking formation of IgG antibodies against lipopolysaccharide of Chlamydia.
In some patients with antibodies against LPS antigen of Chlamydia, specific immunoglobulins G are not present. The findings of isolated anti-LPS IgA/IgM antibodies are to be considered as possibly non-specifically or "false" positive. The aim of this study was to investigate if there is any difference in the level of total immunoglobulins of isotypes IgG and IgG2 in probands with isolated posit...
متن کاملCharacterization of human immunoglobulin (Ig) isotype and IgG subclass response to Bartonella henselae infection.
Serologic parameters of cat scratch disease (CSD) were evaluated by Western blot analysis. Sera from patients with serologically confirmed CSD antigen were screened for immunoglobulin (Ig) isotype-specific as well as IgG subclass-specific reactivity against Bartonella henselae whole-cell antigen. Bartonella-negative control sera were used to determine baseline antibody activity. Heterogeneous B...
متن کاملCriteria for Selection of IgG Isotype and Glycoform of Antibody Therapeutics
LEVEL: INTERMEDIATE T he efficacy of recombinant antibodies (rMAbs) results from their specificity for target antigens and the biological activities (effector functions) activated by the immune complexes formed. Numerous parameters influence the effector function profile (including antibody class, IgG subclass, and glycoform), and their definition offers opportunities for optimizing a recombina...
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ژورنال
عنوان ژورنال: Clinical & Experimental Immunology
سال: 2008
ISSN: 0009-9104
DOI: 10.1111/j.1365-2249.1990.tb06453.x